In a mixing bowl, combine the lean ground beef, breadcrumbs, egg, Parmesan cheese, parsley, garlic, Italian seasoning, salt, and black pepper. Mix well until fully incorporated.
Using your hands, shape the mixture into meatballs, about 1 to 1.5 inches in diameter, yielding around 16 to 20 meatballs.
Preheat your air fryer to 375°F (190°C) for about 5 minutes.
Spray the air fryer basket with cooking spray and arrange the meatballs in a single layer, ensuring they aren’t touching.
Cook the meatballs for 10-12 minutes, flipping halfway through, until they reach an internal temperature of 160°F (70°C).
Remove from the air fryer and let the meatballs rest for a few minutes before serving with your favorite sauce or on a bed of spaghetti.